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Furthermore, with the help of phosphoinositide dependent kinase 1 (PDK1) and mechanistic target of rapamycin kinase complex 2 (mTORC2), respectively, the threonine phosphorylation site (Thr308) and serine phosphorylation site (Ser473) on Akt are phosphorylated ( 6.1.1 The main components and regulators In muscle or adipose tissue (AT), AKT prompts glucose transporter type 4 (GLUT4) to translocate from the cytoplasm to the cytomembrane, thereby mediating insulin-stimulated glucose uptake